#Geo 5 ucr series#

This cancer-prone epithelial population becomes the вЂњcancerization fieldвЂќ in which intra-epithelial neoplasia (IEN, formerly called dysplasia) and Barrett-related esophageal adenocarcinoma (BAc) may develop. Chronic inflammation of the esophageal mucosa results in its metaplastic replacement of the native squamous epithelia by columnar (intestinalized) cells. Longstanding exposure of the esophageal mucosa to gastro-duodenal reflux is the primary risk factor for BarrettвЂ™s esophagus (BE). This study is the first demonstration of a role for T-UCRs in the transformation of BarrettвЂ™s mucosa. Analogous BE-specific T-UCR profiles were shared by human and murine lesions.

Progression from normal to BE to adenocarcinoma was each associated with specific and mutually exclusive T-UCR signatures that included up-regulation of uc.58-, uc.202-, uc.207-, and uc.223- and down-regulation of uc.214+.

#Geo 5 ucr series#

Results were validated in an independent series of esophageal biopsy/surgery specimens and in two murine models of BarrettвЂ™s esophagus (i.e. To identify the T-UCR profiles that are dysregulated in BarrettвЂ™s mucosa transformation, microarray analysis was performed on a discovery set of 51 macro-dissected samples obtained from 14 long-segment BE patients.

More than 90% of UCRs are transcribed (T-UCRs) in normal tissues, and are altered at transcriptional level in tumorigenesis. Ultra-conserved regions (UCRs) are a class non-coding sequences that are conserved in humans, mice and rats.

Received: JAccepted: JPublished: JAbstractД«arrettвЂ™s esophagus (BE) involves a metaplastic replacement of native esophageal squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor for Barrett-related adenocarcinoma (BAc). Keywords: T-UCRs BarrettвЂ™s esophagus BarrettвЂ™s carcinogenesis expression signature * Current address: Sanofi, Cambridge, MA, USA Croce 3 and Massimo Rugge 1,4ДЎ Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, ItalyДў Department of Surgical Oncology and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, ItalyДЈ Comprehensive Cancer Center, Ohio State University, Columbus, OHД¤ Istituto Oncologico Veneto - IOV-IRCCS, Padua, ItalyДҐ Department of Morphology and Embryology University of Ferrara, Ferrara, ItalyД¦ Institute of Cancer Research, London, UKД§ Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PAДЁ Department of Medicine, University of Texas Southwestern Medical Center & VA North Texas Health Care System, Dallas, TXД© ARC-NET Research Centre, University of Verona, Verona, ItalyДЎ0 Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany Souza 8, Caterina Vicentini 9, Edoardo DвЂ™Angelo 2, Jan Bornschein 10, Gerard J.

Matteo Fassan 1,2,3, Luigi DallвЂ™Olmo 4, Marco Galasso 5, Chiara Braconi 6, Marco Pizzi 1, Stefano Realdon 4, Stefano Volinia 3,5, Nicola Valeri 6, Pierluigi Gasparini 3, Raffaele Baffa 7,*, Rhonda F.